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Endocrine Abstracts

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ea0003p158 | Genetics | BES2002

Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

Draper N , Echwald S , Sorensen T , Astrup A , Lavery G , Chalder S , Hewison M , Pedersen O , Stewart P

11beta-hydroxysteroid dehydrogenase regulates glucocorticoid action, by interconverting cortisone (E) to cortisol (F). The Type 1 isozyme (11betaHSD1) is an oxoreductase expressed in adipose tissue, where it may play a role in the pathogenesis of visceral obesity.We have characterised two polymorphic (CA)n microsatellite markers within intron 4 of the HSD11B1 gene, termed (CA)15 and (CA)19. In an earlier study evaluating a 'normal' population (MONICA co...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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